Preadministration of FFP does not alter INR values at 48 hours or more after vitamin K administration. INR reduction is similar for intravenous vitamin K doses of 2 mg or greater. Vitamin K dose, route, and initial INR influence subsequent INR values. Although longer anticoagulation bridge therapy seemed to be associated with higher vitamin K doses, the incidence (p = 0.63) and duration (p = 0.61) were not significant. FFP did not influence INR values at 48 hours. Home warfarin dose did not affect INR responses to intravenous (p = 0.27) or oral vitamin K (p = 0.98). If you get a dangerous bleeding problem while taking warfarin, doctors can turn to an 'antidote' of Vitamin K or a combination of prothrombin complex concentrate (PCC) and fresh frozen plasma to. The INR reduction was similar for intravenous vitamin K doses 2 mg or greater. The dose of vitamin K (p < 0.001), route of administration (p < 0.001), and baseline INR (p < 0.001) influenced subsequent INR values. Intravenous vitamin K reduced INR more rapidly than oral vitamin K (5.09, 1.91, 1.54, and 1.41 vs 5.67, 2.90, 2.14, and 1.58) at baseline, 12, 24, and 48 hours, respectively. Data collected included international normalized ratios (INRs) 12 hours, 24 hours, and 48 hours prior to vitamin K administration intravenous or oral vitamin K dose and whether or not fresh frozen plasma (FFP) was administered. This was a chart review of 400 patients who received vitamin K for reversal of warfarin effects between February 2008 and November 2010. To determine factors influencing the extent and rate of INR reversal with vitamin K in the acute/critical care setting. However, the optimal dose and route of vitamin K that does not increase the duration of bridging therapy is unknown. Vitamin K is commonly used for reversal of anticoagulation of warfarin.
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